Circulating serum C- reactive protein: a prognostic marker in naive patients with cancer at the Yaounde General Hospital

  • Luc-Aimé Kagoue Simeni Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon
  • Jean-Thierry Ebogo Belobo Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon
  • Lawan Loubou Mohamadou Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon
  • Gregoire Mbassa Nnouma School of Health Sciences, Catholic University of central Africa
  • Idrissa Abame School of Health Sciences, Catholic University of central Africa
  • Aurelie Hapi Tchuisseu School of Health Sciences, Catholic University of central Africa
  • Sabine Dooh Ngalle School of Health Sciences, Catholic University of central Africa
  • Sorelle-Hémérode Mbock School of Health Sciences, Catholic University of central Africa
  • Michel Kengne School of Health Sciences, Catholic University of central Africa
  • Mbarawa Marat Kofia Ibrahim Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon.
  • Awung Nkeza Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon
  • Etienne Atenguena Okobalemba Yaounde General Hospital, Yaounde, Cameroon
Keywords: CRP, cancer, inflammation, prognostic

Abstract

In Cameroon, the main determinant of cancer mortality is the advanced stage at the time of diagnosis. The purpose of this work is to determine the relationship between C-reactive Protein (CRP) concentration and advanced cancer stage. This is a cross-sectional study conducted at Yaoundé General Hospital. 276 naive patients with histological evidence of cancer were included in this study. Serum CRP level was correlated with the specific characteristics of the tumor. The study population was made of 74% women and 26% men with a minimum age of 22 years and a maximum age of 80 with an average age of 46 years. The cancer type with the highest prevalence was breast cancer (43.5%), followed by Kaposi's sarcoma (8.7%), Non Hodgkin Lymphoma (8.7%), CRP values were Classified into two groups based on pathological values (CRP≥ 6 mg/l) and non-pathological values (CRP <6 mg/l). The elevated CRP concentration was not significantly associated with the presence of metastasis M (P = 0.074), T-cancer stage (P = 0.09), N-lymph nodes (P = 0.111), advanced histological grade G-3 (P = 0.115) and cancer type (P = 0.124). Our study shows that elevated serum CRP is not a marker of cancer extension.

Author Biographies

Luc-Aimé Kagoue Simeni, Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon

Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon &
School of Health Sciences, Catholic University of central Africa

Jean-Thierry Ebogo Belobo, Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon

Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon
Institute of Medical Research and Medicinal Plant Study, Yaounde, Cameroon

Lawan Loubou Mohamadou, Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon

Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon &
National Radiation Protection Agency, Yaounde, Cameroon

Gregoire Mbassa Nnouma, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Idrissa Abame, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Aurelie Hapi Tchuisseu, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Sabine Dooh Ngalle, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Sorelle-Hémérode Mbock, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Michel Kengne, School of Health Sciences, Catholic University of central Africa

School of Health Sciences, Catholic University of central Africa

Mbarawa Marat Kofia Ibrahim, Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon.

Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon. &
Higher Institute of Sciences Health Techniques and Management of Garoua, Cameroon

Awung Nkeza, Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon

Department of Medical Laboratory Sciences, Faculty of Health Science, University of Buea, Cameroon

Etienne Atenguena Okobalemba, Yaounde General Hospital, Yaounde, Cameroon

Yaounde General Hospital, Yaounde, Cameroon

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Published
2018-11-30