Pharmacological evaluation of Allium cepa extract as hepatoprotective potential in albino rat
Objective: The study was designed to evaluate the hepatoprotective potential of Allium cepa extract in carbon tetrachloride (CCl4) induced hepatotoxicity in albino rats. Methods: All albino rats were divided into four groups having six animal in each (n=6) to evaluate the efficacy of Allium cepa extract in comparison with standard drug Silymarin. The drugs were orally administered to rats for 10 days in CCl4 model and animals were weighed periodically. At the end of the study, blood samples were collected for the test of SGOT, SGPT, ALP, total bilirubin, and total protein levels. The antioxidant enzyme parameters such as LPO, MDA, GSH, SOD, and CAT were also performed for all group of animal. The liver tissues of all groups were collected after scarifying the animals and histopathological examination reported for confirmation of potential activity. Results: All the test group of rats was significantly reduced levels of SGOT, SGPT, ALP, total bilirubin, in CCl4 induced hepatotoxic models. There was a significant increase in total protein level in all the tested formulations. The antioxidant enzyme parameters such as LPO, MDA, GSH, SOD, and CAT were shows significant improvement in the treatment group as compared to disease control. The extract treated rats effectively preserved the structural integrity of the hepato-cellular membrane and liver cell architecture damaged by CCl4. Conclusion: It can be concluded that the Allium cepa extract possesses hepatoprotective activity in CCl4, induced hepatotoxicity in rats. This may be effectively used as a hepatoprotective agent in the management of hepatitis caused by various toxins.
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