@article{Ravi Kumar_S.Nag_2021, title={A Study to Evaluate Hemodynamic Response in Patients Undergoing Laparoscopic Surgeries Premedicated with Oral Clonidine in a Tertiary Medical Centre of South Bihar}, volume={4}, url={https://ijhcr.com/index.php/ijhcr/article/view/1836}, abstractNote={<p>Introduction: Insufflation of CO2 into the peritoneal cavity, ports from which instruments can be negotiated into the distended abdomen, and various changes in patient position depending on the type of operation are all required during laparoscopic procedures. Increased intraabdominal pressure (IAP), blood pooling in the periphery, and stress hormone responses (cortisol, epinephrine, and nor-epinephrine) all lead to the hemodynamic variations. Furthermore, patient’s IAP is elevated, and his or her location is changed, in laparoscopic procedure making ventilation difficultAim : To observe hemodynamic changes during pneumoperitoneum (without and with) oral clonidine150 ug in laparoscopic surgery.<br>Material and Methods: This is a prospective observational study, will be conducted on 60 study subjects at Narayan medical college and Hospital, Rohtas , South Bihar. Study subjects will be selected as per Inclusion and exclusion criteria from general surgery theatre complex of the hospital. Patients will be divided into two groups (30 each)Group A (Clonidine) 150 ug - Patients will be given tab. Clonidine 150 ug orally 60 minutes prior to induction.Group B (Control) - Patients will be given sugar coated placebo tablet 60 minutes prior to induction.Hemodynamic assessment was done in both the groups and compared.Result : SBP,DBP ,MAP was also measured at the time of induction, 5 min after induction, 5 min after insufflation , 15min and 30 min after insufflation and it was found that there was statistically significant difference between the two groups, with p value <0.005 each time respectively.Conclusion:Prior to laparoscopic surgeries in adults, oral clonidine 150 mg will effectively blunt the hemodynamic response to pneumoperitoneum. Because of this benefit and the low, easily treatable side effect profile, regular use is recommended.</p>}, number={12}, journal={International Journal of Health and Clinical Research}, author={Ravi Kumar and S.Nag}, year={2021}, month={Jul.}, pages={22–27} }