TY - JOUR AU - Amena Tasneem, AU - Helena Vemuri, AU - Mohammad Ibrahim Shaik, AU - Mohammed Siddique Ahmed Khan, PY - 2021/12/31 Y2 - 2024/03/28 TI - Comparative study of HbA1c and superoxide dismutase in type II diabetes mellitus JF - International Journal of Health and Clinical Research JA - Int. J. Heal. Clin. Res. VL - 4 IS - 24 SE - Articles DO - UR - https://ijhcr.com/index.php/ijhcr/article/view/3761 SP - 81-83 AB - <p>Introduction: Diabetes mellitus (DM) is a complex metabolic disorder characterised by chronic hyperglycemia with disturbances of carbohydrate, lipid and protein metabolism resulting from defects in insulin secretion, insulin action or both. Chronic hyperglycemia is linked to oxidative stress, which involves increased reactive oxygen species (ROS) production. Materials and methods: The is a prospective and observational study conducted at Tertiary care teaching hospital comprised of 60 patients between age groups 30-70 years of both sexes of DM Type 2 reporting for treatment. The patients were divided into Case group (Type 2 DM) and Control group (Healthy Subjects). The criteria for the diagnosis of Type 2DM were the same as the one which was given by the American Diabetes Association (ADA). Result: Among 60 patients, 38 were male (63.3%) and 22 were female (36.6 %) compared with control group 36 males (60%) and 24 females (40%) in control groups (p value 0.58). In this study, the maximum number of patients were in the age group of 51-60 years which were 31.6% (n =19) followed by age group 61–70 years having 28.3% (n = 17) in this group and 21.6% were 41-50 years. FBS in case group was 166.4±16.63 mg/dl and in control group 82.86±11.59 mg/dl. SOD in case group was 658.46+64.73 (U/gHb) and in control group 987.52+73.54 (U/gHb). HbA1c in case group was 7.98±1.31% and in control group 5.78±0.94%. Conclusion: The present study has proved the presence of oxidative stress in diabetic patients as assessed by decrease in SOD levels. Significant decrease in SOD in patients with poor glycemic control and negative correlation between HbA1c and SOD shows that the glycemic control has an influence on the oxidative stress in diabetic patients.</p> ER -