International Journal of Health and Clinical Research

Morphological variations in Common Facial Vein with variant venous drainage

2024-10-22T11:02:43+00:00

Background: In depth anatomical knowledge of the facial vasculature is crucial not only for anatomists but also for Oto-rhino-laryngologists, reconstructive and oral and maxillofacial surgeons. The common facial vein (CFV) is a vital component of the facial venous system, which exhibits morphological variations that impact surgical and diagnostic procedures. The present study investigates the CFVs anatomical diversity, focusing on the divergent venous drainage patterns. Aim: To describe rare anatomical variations of the common facial vein. Material and Methods: The study was conducted in the Department of Anatomy, of a tertiary care establishment (Medical College) in Western Maharashtra, during the period 2023-24. Head and neck region of 20 cadavers (11 males and 9 females) i.e. 40 sides of embalmed cadavers of different age group were carefully dissected, and studied for variations in the formation and drainage pattern of Common facial vein. Results: In 34 sides (85 %), the common facial vein (CFV) terminated into the Internal jugular vein (IJV) as per standard anatomic description. On one side of the cadaver, the left common facial vein (2.5%) was found draining into the anterior jugular vein (AJV) as well as into the internal jugular vein (IJV). In three cadavers (7.5%), the CFV was found to be draining into the AJV. In two cadavers (5%), the facial vein (FV) was not receiving the anterior division of retromandibular vein and was directly draining into the IJV. Conclusion: A sound knowledge of variation in the course and termination of common facial vein is very useful for the clinicians and surgeons who perform procedures like cannulation and vein graft harvesting for endarterectomies of the head and neck region.

Formulation and evaluation of fast dissolving tablet-bilastine

2024-10-22T11:35:49+00:00

In the present, study to establish Fast dissolving tablets of Bilastine by using different ratio of superdisintegrants. The tablets were prepared by using two superdisintegrants( croscarmellose sodium, sodium starch glycolate) in different composition. Development of Fast dissolving tablets of Bilastine were designed to give rapid onset of action and help those patients who have difficulty in swallowing the drug . The present study aims to improve patient compliance, reduce the condition of dysphagia and also reduces the multiple dosing. Tablets were evaluated by different parameters such as Weight variation, Tablet hardness, Friability ,Mouth feel ,Wetting time, Water absorption ratio, In vitro drug release study, In vitro disintegration time, Drug content uniformity, Accelerated stability testing. The present study concludes that fast dissolving tablets of Bilastine with different composition of superdisintrgants shows rapid disintregation time as well as dissolution profile which represents rapid onset of action of the formulation.

Clinical Profile and Outcome of Patients Admitted with Rodenticide Poisoning – A Single Centre Experience from Andhra Pradesh

2024-11-16T12:58:14+00:00

Introduction: Rodenticides are easily available and inexpensive poisons found in almost every house in India to prevent rodent infestation. Rodenticide poisoning is the second most common type of poisoning in the Indian Subcontinent, and there is a limited amount of research on it. The aim of our study is to evaluate the clinical profile of patients admitted with rodenticide poisoning and to correlate various parameters like serum bilirubin, and serum creatinine with mortality. Methodology: A prospective hospital-based study of 100 consecutive cases diagnosed as Spontaneous Pneumothorax from January 2019 to September 2020. Every patient underwent comprehensive history taking, in-depth clinical examination, and investigations. Data were entered into Excel spreadsheets in 2019. Data was presented by using frequency and percentage and descriptive statistics were used. Results: A total of 100 patients were included in the study. The most commonly consumed poison was a phosphorus-based paste. The most common symptom reported was abdominal pain (90%). Warfarin-based baits were associated with a high incidence of bleeding manifestations. The mortality rate was 20%. Additionally, a delay in hospitalization was found to be a significant risk factor for mortality. Higher mortality rates and was accompanied by elevated bilirubin and SGPT levels. Conclusion: In this study, mortality was 20%, all due to phosphorus compound. Mortality was common in phosphorus compound, particularly in those who developed jaundice on day 4 of admission which is reflected by elevated bilirubin and serum creatine level.