Study of Lipid Profile and Thyroid Function Abnormality In Children Of Nephrotic Syndrome

Abstract

Background: Hypercholesterolemia and subclinical hypothyroidism were common problem in nephrotic syndrome. Monitoring of lipid profile to done not only in the diagnosis and also in relapse cases. Because in relapse cases serum cholesterol persistently elevated and predispose to the development of atheroslerosis.Aims and Objectives: To study the correlation between lipid and thyroid profile and different types of nephrotic syndrome in children between 1 to 12 years and also study the association between serum albumin with lipid profile and TSH. Materials &Method: 80 cases of different types of nephrotic syndrome included in our study that includes first episode, relapses, Steroid dependent nephrotic syndrome(SDNS), Steroid resistant nephrotic syndrome(SRNS) and in remission. Only one value is taken and its distribution in different types of nephrotic syndrome was analysed. Results:  Males are affected more with mean age of presentation of 6.9 years. SRNS cases cholesterol level significantly elevated compared to other types. T3, T4 and TSH were within normal limit, negative correlation between albumin with cholesterol and TSH. Conclusion: Serum cholesterol should be monitored in relapse cases, because persistent elevation in relapse cases predispose to development of atherosclerosis. In SRNS cases cholesterol level was highly elevated and may require lipid lowering agents. No need of routine thyroid screening in a case of nephrotic syndrome.

Keywords: Nephrotic syndrome, Lipid profile, Thyroid function