Correlation of iron deficiency anaemia with HAEMOGLOBIN A1C At A Tertiary Care Teaching Hospital In Uttar Pradesh

Abstract

Background-Iron deficiency anemia(IDA) is the commonest form of nutritional anemia worldwide, posing wide public health risks. It can increase the red blood cell turnover, which can increase glycation of Hb leading to  higher HbA1c values.Aim- The Aim of the study is to correlate the status of iron deficiency anaemia with glycosylated haemoglobin in adults belonging to the age group of 18- 60yrs. Objectives- To study iron deficiency anaemia for proper screening of patients for early prevention and management. To determine the effect of iron deficiency anaemia on the HbA1c levels.To determine whether the HbA1c levels were increased among anaemic patients. If so, iron deficiency has to be corrected before any diagnostic and therapeutic decision is made based on the HbA1c level.Settings&Design-The present study is a Prospective, Interventional, and Randomized study conducted in tertiary care rural teaching hospital in Uttar Pradesh.  A total of 150 individuals (Patients-100, Control-50) were recruited in the study. Age Group of 15-60 years was studied. Proper Ethical approval from Institutional Ethical Committee was taken and all the participants. A written Informed Consent was obtained from each patient and control  before starting the procedure. Material&Methods-150 participants of our study underwent clinical assessment, their history was taken, investigations including anemia profile and HbA1C levels were done. Anemia correction was done with iron supplementation and HbA1C level was measured post 2 month. Statistical analysis was performed using SPSS (Statistical Package for the Social Sciences) for Windows (version 16.0).Results&Conclusion-Our study shows that there is a decrease of HbA1c levels in patients of IDA as the mean value of HbA1c(%) in intervention group was at 7.66 at base line which was significantly lower than that of controls(baseline HbA1c = 4.92). Also there is an decrease in level HbA1c after 2 months of treatment as the mean value of HbA1c (%)in patients was 5.40 at 2 month and the mean HbA1c of controls over 2 months period was 5.5.

Keywords- Iron Deficiency Anemia, HbA1C, Hemoglobin