Assessment of insulin resistance levels among subjects with normal glucose tolerance, hyperinsulinemia with normal blood glucose tolerance and newly diagnosed T2DM

Abstract

Background:Hyper-insulinemic euglycemic clamp (HEC) is known to be the "gold standard" for the measurement of insulin sensitivity. The present study compared IR levels among subjects with NGT, hyperinsulinemia with normal blood glucose tolerance (HINS) and newly diagnosed T2DM. Materials & Methods:75 subjects were divided into 3 groups of 25 each. Group I was subjects with NGT, group II was hyperinsulinemia with normal blood glucose tolerance (HINS) and group III was newly diagnosed T2DM. Oral glucose tolerance test (OGTT) was administered to all. Assessment of weight, BMI, SBP, DBP, TG, LDL, HDL, TC and HOMA- IR was done.Results: Group I had 15 males and 10 females, group II had 13 males and 12 females and group III had 11 males and 14 females. The mean BMI (Kg/m2) was 22.3, 27.3 and 26.4, waist (cm) was 74.2, 86.4 and 90.2, SBP (mm Hg) was 124.0, 120.6 and 126.8, DBP (mm Hg) was 74.2, 80.4 and 76.4, TG (mmol/L) was 1.24, 2.06 and 1.76, LDL (mmol/L) was 2.54, 2.94 and 3.12, HDL (mmol/L) was 1.80, 1.52 and 1.06, TC (mmol/L) was 4.90,5.26 and 4.74, Glu 0 (mmol/L) was 4.11, 4.74 and 5.24, Glu 120 (mmol/L) was 5.44, 6.21 and 13.6 and HOMA- IR was 0.94, 2.56 and 3.02 in group I, II and III respectively. The difference was significant (P< 0.05).Conclusion:Insulin resistance existing in subjects with normal glucose tolerance, subjects with hyperinsulinemia with normal blood glucose tolerance (HINS) and in newly diagnosed T2DM.