To Compare efficacy of carboxymethyl cellulose .5% eye drops versus use of 0.5% carboxymethylcellulose eye drop with combination of 0.1% tacrolimus ointment twice daily for treatment of severe dry eyes
Keywords:Carboxymethylcellulose, Tacrolimus, Dry eye
Background: Dry eye disease is a common disorder provoking changes in tear film and ocular surface. Untreated dry eye could cause ocular infections, corneal ulcer and blindness. Only a few drugs are authorized so far for the treatment of severe dry eye disease and the possibilities of evolution in this sector are immense.Objectives: Compare efficacy of carboxy methyl cellulose .5% eye drops versus use of 0.5% carboxy methylcellulose eye drop with combination of 0.1% tacrolimus ointment twice daily for treatment of severe dry eyes.Material and Methods: 40 patient presenting with severe dry eye were selected randomly. They were divided into 2 groups. Group I received CMC.5% eye drops four times a day and group II received of 0.1%tacrolimus ointment two times daily and .5% CMC eye drops 4times a day. All patients were evaluated on day 0, 2 weeks, 1 month, 3 month and 6 month for relief in ocular symptoms and diagnostic dry eye tests.Results:The mean age in group I was 40.72 ± 6.85 years and in group II was 39.2 ± 5.28 years. Ocular discomfort, dryness and tearing were seen in all the cases. Comparison of different parameters after six months of treatment between group I and II showed that the comparision of net score in two groups is statistically significant(p < 0.05). Conclusion: There was statistically significant difference between the outcome of two groups.Group 2 patients who used combination of of 0.1%tacrolimus ointment two times daily along with CMC 0.5% eye drops 4 times a day were better relieved as compared to patients in group 1 who used 0.5% CMC eye drops four times daily for treatment of severe dry eyes
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Copyright (c) 2021 Prerana Agarwal, SD Tayal, Ankur Gautum
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