Association between Lipid Profile and Lipoprotein(a) levels in individuals with Hypercholesterolemia

Abstract

The aim of this study is the association between Lipid Profile and Lipoprotein (a)Lp(a) levels individuals with Hypercholesterolemia (i.e) Total Cholesterol (TC) with >200mg/dLFasting.blood samples were collected from both males and females and were divided into two groups – Group -1 with Total Cholesterol < 200mg/dL (n= 25) and Group - 2 with Total Cholesterol > 200mg/dL (n= 25) . Serum Lp(a) was determined by Particle Enhanced Immunoturbidimetric Assay and Lipid Profile,which includes Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and Triglycerides (TGL) were determined in fully-automated analyser.Non-HDL-Cholesterol and LDL Cholesterol (LDL-C) was calculated by Friedewald’s formula. A significant increase in Serum Lp(a) levels , HDL - C ,TGL ,Non- HDL-Cholesterol and LDL-C was observed in Group-2 individuals when compared with Group1.There was significant positive correlation (r) observed between Serum Lp(a) and Total Cholesterol and Serum Lp(a) and LDL-C with r ═ 0.61 and 0.69 respectively in Group-2 individuals.The subjects with high Cholesterol and high Lp(a) levels are at a high risk of developing Coronary heart disease which causes 40-50% of deaths in India . This study supports the need to intensify lipid management in individuals with high Lp(a) levels.