Association between Lipid Profile and Lipoprotein(a) levels in individuals with Hypercholesterolemia
Keywords:Lipoprotein (a) (Lp(a) , Total Cholesterol (TC) , HDL-Cholesterol (HDL-C) , Triglycerides (TGL) Non-HDL-Cholesterol , LDL Cholesterol (LDL-C) and Coronary heart disease.
The aim of this study is the association between Lipid Profile and Lipoprotein (a)Lp(a) levels individuals with Hypercholesterolemia (i.e) Total Cholesterol (TC) with >200mg/dLFasting.blood samples were collected from both males and females and were divided into two groups – Group -1 with Total Cholesterol < 200mg/dL (n= 25) and Group - 2 with Total Cholesterol > 200mg/dL (n= 25) . Serum Lp(a) was determined by Particle Enhanced Immunoturbidimetric Assay and Lipid Profile,which includes Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and Triglycerides (TGL) were determined in fully-automated analyser.Non-HDL-Cholesterol and LDL Cholesterol (LDL-C) was calculated by Friedewald’s formula. A significant increase in Serum Lp(a) levels , HDL - C ,TGL ,Non- HDL-Cholesterol and LDL-C was observed in Group-2 individuals when compared with Group1.There was significant positive correlation (r) observed between Serum Lp(a) and Total Cholesterol and Serum Lp(a) and LDL-C with r ═ 0.61 and 0.69 respectively in Group-2 individuals.The subjects with high Cholesterol and high Lp(a) levels are at a high risk of developing Coronary heart disease which causes 40-50% of deaths in India . This study supports the need to intensify lipid management in individuals with high Lp(a) levels.
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Copyright (c) 2021 Afshan Rafi, T. Sudhakar
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