Role of resistin in gestational diabetes in Eastern India

Abstract

Background: Gestational diabetes leads to complications due to glucose intolerance whereas resistin induces insulin resistance concerned in the pathogenesis of obesity and type 2 diabetes commonly associated with GDM. Thus the aim of the study is to investigate the relationship between resistin levels and GDM and the possible benefits of the metabolic profile. Methods: The cross-sectional study consists of 36 pregnant females routinely examined for GDM with a 75 g 2 hour oral glucose tolerance test (OGTT) at the gynecological out-patient clinic were taken as cases whereas 32 women with normal glucose tolerance (NGT) were taken as control subjects. The cases as well as controls were assayed for serum resistin as well as serum insulin after matched for age, gestational age as well as BMI for this study. Results: Serum resistin levels were increased in GDM cases as compared to controls and were statistically significant (36.24 ± 14.62 vs 15.29 ± 8.51 ng/ml; p < 0.0001). Moreover, serum Insulin levels were higher in GDM cases as compared to controls which were statistically significant (16.92 ± 8.23 versus 8.84 ± 4.11 μ IU/ml; P < 0.0001). Conclusion: Our study reveals higher serum resistin and higher serum insulin values in GDM cases may be used for screening tests in the diagnosis of the disease.