Association of Thyroid Dysfunction with Metabolic Syndrome: A Real-world Study

Abstract

Objective: Objective of this study was to determine the prevalence of thyroid dysfunction in metabolic syndrome and to find out the association of thyroid dysfunction and metabolic syndrome.Material and methods: In this retrospective observational real word study 110 consecutive patients with metabolic syndrome criteria were included. Detailed history including medications, and anthropometric measurements were collected in a semi-structured proforma.Result: In this study, prevalence of thyroid dysfunction in metabolic syndrome patients is 20%. Thyroid dysfunction is more common in female (58.18%) than male (41.82%) with metabolic syndrome. Among the thyroid dysfunction patients 3.6% and 16.4% had overt hypothyroidism and subclinical hypothyroidism respectively. No patients had either subclinical hyperthyroidism or overt hyperthyroidism. A significant negative correlation between T4 and waist circumference (r=-0.169; p=0.05) and a positive correlation between TSH and waist circumference (r=0.189; p=0.042) was found.Conclusion: Thyroid dysfunction is prevalent in metabolic syndrome and more common in female. Subclinical hypothyroidism is the most common thyroid dysfunction in metabolic syndrome patients. There is a significant negative correlation between T4 and waist circumference and a significant positive correlation between TSH and waist circumference.