Assessment of the effect of supplemental oxygen on development of retinopathy of prematurity

Abstract

Background:Retinopathy of prematurity is a vasoproliferative disorder that affects premature infants. The present study was conducted to assess the effect of supplemental oxygen on development of retinopathy of prematurity.Materials & Methods: 90 neonates of 0-28 day’s old of both gender with possibilities of ROP were included and assessment of retinopathy was done.Results: There were 1 ROP +ve and 12 ROP-ve neonates seen within 24-72 hours of oxygen inhalation, 6 and 10 in 73-120, 22 and 2 in 121-170 and 36 and 1 >170 hours of oxygen inhalation respectively. There were 8 ROP+ve and 10 ROP-ve neonates seen with 85-89 Oxygen saturation, 25 and 12 with 90-94 Oxygen saturation and 32 and 3 with 95-99 Oxygen saturation respectively. The artial pressure of oxygen (PaO2) was 70-99 seen in 13 and 8, 100-150 seen in 40 and 14and >150 in 12 ROP +ve and 3 ROP-ve respectively. The difference was significant (P< 0.05).Conclusion: Retinopathy of prematurity was seen with oxygen supplementation.