Morphologic spectrum of co-existing lesions in breast malignancy – A study of mastectomy specimens

Abstract

Breast lesions is a family of heterogeneous entities with varying forms of presentation, morphology and clinical nature. Most of these lesions are traditionally classified into benign and malignant conditions. However, some lesions show marginal features and lie in a grey-zone between benign and malignant due to unreliable predictability. Pathological categorisation of such lesions is challenging, and under-diagnosis may leads to over-treatment or under-treatment. The shortage of these lesions makes acquisition of clinical evidence problematic and restricts the advancement of a sufficient evidence base to support informed decision making by clinicians and patients. Emerging molecular evidence is providing a greater understanding of the biology of these lesions, but this may or may not be reflected in their clinical behaviour. In the present study. we discuss some breast lesions that may leads to cancer malignancy. The idea of categories of breast lesions of uncertain malignant nature and breast lesions of limited metastatic potential, are recommended.