To evaluate the role of platelet rich plasma in treatment of various enthesopathies: A prospective study

Abstract

Background: Plantar fasciitis and epicondylitis are one of the most common enthesopathies affecting human body. Platelet rich plasma (PRP) is a bioactive component of whole blood that can enhance human stromal and mesenchymal stem cell proliferation. PRP is dependent on these growth factors for its regenerative properties. PRP has high amount of cytokines and growth factor which increases cellular movement, matrix synthesis, and increase in number leading to increase regenerative abilities of tendons. The aim of this study was to evaluate the role of platelet rich plasma in treatment of various enthesopathies.Material and Method: A total number of 52 patients, 26 each of plantar fasciitis and epicondylitis who presented to Orthopaedics OPD of TeerthankerMahaveer Medical College and Research Centre, Moradabad and fulfilled the inclusion criteria, were included in this prospective study. Pre procedure investigations were done and patients were injected freshly prepared platelet rich plasma at effected site and followed immediately after giving PRP injection and then at an interval of 1, 2, 3 months and visual analogue scale was used to assess relief in pain symptom.Result: There was gradual decrease in pain severity and average VAS score in patients of plantar fasciitis and epicondylitis at monthly follow ups after giving PRP injection. No patient was lost to follow up. There was a statistically significant (p<0.001) difference in the median scores of visual analogue scale among patients with Plantar fasciitis and Lateral epicondylitis between immediate follow-up and follow-up at subsequent months. The median vas score was 7 at pre injection time which decreased to 2 at the end of 3rd month follow up. Conclusion: This prospective study indicates that PRP injection is safe and has potential to reduce pain in various enthesopathies.