Histomorphological spectrum and prevalence of various kidney lesions: an autopsy study at the tertiary care center

Abstract

Background: For establishingcell and organ culture as well as xenotransplantation, autopsy assists in identifying the normal as well as diseased human tissue for morphologic studies. It also helps in discovering new diseases and evaluating the toxic effects of drugs and therapies. Kidneys are also affected by chronic inflammatory lesions, neoplasms, toxic effects of various drugs, and metabolic disorders.Aim and objective: To evaluate histomorphological spectrum and prevalence of various kidney lesionsin patients with chronic kidney disease (CKD) from autopsy specimen. Material and method: Three hundred and eighty autopsies were studied in two year after gross pathological examination. Tissue sections were examined withhematoxylin and eosin stain. Based on gross and microscopic examination lesions were categorized into glomerular, vascular, tubular, and interstitial lesions. Result:The majority of the specimens were from male (78.4%) patients. The mean age was 55.61+ 10.57 years.The most commonlesions were of cloudy swelling [47 (12.3%)] followed by 36 (9.4%) cases of changes of CKD mainly at the subcortical region, 35(9.21%) cases with CPN, 27 (7.1%) case of acute tubular necrosisand 9 (2.3%) case of tubulointerstitial disease. Conclusion:Glomerular and interstitial fibrosis lesions, the inflammatory chronic infiltrate, as well as vascular lesions are commonly occurring lesions in patients with CKD.