Comparative assessment of morning versus evening dose of levothyroxine in hypothyroid patients

Abstract

Background:Hypothyroidism denotes the pathological condition of thyroid hormone deficiency. If untreated, it can lead to various adverse health effects. Treatment with thyroxine replacement can mitigate the impact of hypothyroidism.Aims & Objectives:To compare the efficacy of morning versus evening dose of levothyroxine and To compare the effect of morning versus evening dose of levothyroxine on lipid profile. Materials and methods: This observational study was conducted at Saraswati Medical College, Unnao on 76 subjects with hypothyrodism.

Result:There was no statistically significant difference in the changes in serum TSH and T₄ level between patients taking evening dose of levothyroxine with those taking morning dose. Serum lipid profile over the 12 and 24 weeks period  has not shown any statistically significant difference.Conclusion:Evening schedule of Levothyroxine dose is as efficacious as morning dose in terms of thyroid profile and lipid profile. Hence, change of scheduling can be effected if needed to achieve better complaince.

Keywords: Hypothyroidism,Thyroxine, Lipid profile, Metabolism