The Association Between Time Domain Analysis Of Heart Rate Variability With Glycated Hemoglobin And Duration Of Type 2 Diabetes Mellites

Abstract

Aim:The aim of present study was to investigate the association of impairment heart rate variability with glycatedhaemoglobin and duration of diabetes in type 2 Diabetes Mellitus (T 2 DM) subjects. Material and Methods: The present study was a cross sectional study carried out in 60 age and gender matched individuals selected after proper screening with inclusion and exclusion criteria, out of them 30 were T 2 DM and control group consisted of 30 healthy non-diabetic individuals. All the participants of study were subjected to measurement of 5 minutes ECG using Niviqure data acquisition system and time domain analysis of heart rate variability was done. HbA1c levels were estimated by high performance liquid chromatography. Statistical analysis was done using MS office excel 2020 software. Results: The study revealed that time domain analysis parameters of Heart rate variability (HRV)were significantly (P<0.05) reduced in diabetic patients viz., standard deviation of normal to normal R-R interval (SDNN 22.7±6.6), Root mean square of successive difference between normal to normal beat (RMSSD 19.84±4.22) and percentage of adjacent NN intervals that differ from each other by more than 50 ms (pNN50 1.81±1.14), and respectively) compared to non-diabetic (SDNN,RMSSD,pNN50 30.89±7.6, 22.7±2.85 and 3.19±2.12 respectively). It was also found that there is a negative correlation between HbA1c values of subjects and parameters of HRV. Conclusion: chronic elevated hyperglycaemia leads to cardiac autonomic neuropathy that can be screened and detected by simple, yet sensitive tests measuring heart rate variability