To Study The Prevalence and Pattern Of Resistance in Typhoid Fever Including Multi Drug Resistant Typhoid Fever (MDRTF) And Nalidixic Acid Resistant Salmonella Typhi (NARST) in a Tertiary Care Hospital

Abstract

Typhoid fever is a global health problem. Its real impact is difficult to estimate because the clinical picture is confused with those of many other febrile infections. Aim and Objectives: To Study The prevalence and pattern of resistance in typhoid fever including MDRST and NARST. Materials and Methods: A Descriptive study / Case control study Were Conducted of All children admitted with clinical suspicion of typhoid fever and All children with fever (38oC and above) for atleast three days, with a laboratory confirmed positive culture of S.typhi.(WHO definition for confirmed cases of typhoid fever) 38. in All medical wards of Patna Medical College and Hospital, Patna (PMCH) From February 2020 to January 2021. Results: Incidence of multidrug resistant and quinolone resistant typhoid fever was found to be 43.6% and 20.5% respectively which vary with time and place. Conclusion: Hence there is a constant need to monitor antibiotic sensitivity pattern of S.typhi and periodically review the antibiotic policy in the hospital and the community so as to effectively utilize these antibiotics.