A study on Epidemiology and Symptomatology and Glomerular Filtration Rate (GFR) in Pre-dialysis Chronic Kidney Disease patients

Abstract

Introduction: Longitudinal studies have established that Cardiovascular Disease (CVD) occur more frequently and are the leading cause of death in Chronic Kidney Disease (CKD). Dyslipidemia has been established as an important risk factor in the pathogenesis of CVD in CKD patients. Objectives: Present study was aimed to evaluate (in CKD patients), Demography along with Symptomatology and Glomerular Filtration Rate (GFR) in Pre-dialysis Chronic Kidney Disease patients (Study cases). Methods: Present Cross-sectional study, conducted in Department of Medicine, R.D. Gardi Medical College and CRG hospital, Ujjain, M.P. from 1 st January 2015 to 31st July 2016. We studied 115 pre-dialysis CKDcases and 100 age & sex matched controls. CKD was diagnosed as per 2012 KDOQI Criteria. Result: In CKD cases, maximum 23.47% cases belonged to fifth decade. Mean age was 48.99 ± 16.74. Male to Female ratio was1.21: 1. In the present study of 115 Study cases, pallor was present in ninety five (82.6%) cases, followed by facial puffiness in eighty eight (76.5%) cases, pedal oedema in eighty two (71.3%) cases and oliguria in eighty (69.5%) cases. Hypertension was evident in eighty seven (75.6%) cases. The mean Serum Creatinine, Urea, Total Protein, albumin, Potassium, Phosphorus value were increased in Study group as compared to control group. The mean Serum Calcium value was decreased in Study group as compared to control group.