A Comparitive Study of Granisetron and Palonosetron as Antiemetics for Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries

Abstract

Laparoscopic surgeries are associated with an appreciably high rate of post operative nausea and vomiting (PONV). This study was designed to compare the effectiveness of Granisetron with that of Palonosetron for prevention of PONV after laparoscopic surgery. Methods:In a randomized, prospective study, 50 adult patients of both sexes received Granisetron 2.5mg and Palonosetron 75mcg intravenously at the end of surgery. Perioperative anaesthetic care was standardized in all patients. Patients were then observed 24 hours after administration of the study drug.Results:A complete response (defined as no PONV and no need for another rescue antiemetic) was achieved in 76% of the patients given Granisetron and 84% of the patients given Palonosetron with (P<0.05%). No significant difference observed in the recovery time from anesthesia between the two drugs and slight difference in the adverse events were observed between the two groups.
Conclusion:This study concludes that the prophylactic intravenous administration of Palonosetron is more effective drug than Granisetron for controlling postoperative nausea and vomiting with less incidence of side effects.