High-sensitivity C-reactive protein, Malondialdehyde and their association with Glycated hemoglobin (HbA1c) in type 2 diabetes patients

Abstract

Background: Evaluation of High-sensitivity C-reactive protein, malondialdehyde(MDA)levels in type 2diabetic patients compare with healthy controls and correlate these levels with glycated hemoglobin (HbA1C) and insulin resistance.Materials and Methods: A prospective evaluation study was carried out in the Department of Biochemistry, Netaji Subhas Medical College and Hospital, Patna, Bihar India. The study population consisted of 200 subjects divided in to two groups viz., diabetic patients (type 2 diabetic subjects; n=100) and non- diabetic participants (n=100). 100 male and 100 female were include in this study. The age of the patients of both sex were 30-50 years. Serum hs- CRP and insulin was assessed by ELISA, malondialdehyde (MDA) was assessed by Thiobarbituric Acid Reactive Substances (TBARS) method and other routine investigations were carried out by standardized protocols with vitros 350fully automated analyzer. Results: The mean serum hs-CRP and MDA levels were significantly highin type 2 diabetic patients compared with healthy patients. Hs-CRP and MDA levels we are shown significant positive correlation with glycocylated hemoglobin (HbA1C), insulin resistance, triglycerides and negative correlation with HDL cholesterol. Conclusion: Elevated hs - CRP, MDA levels are potentially important diagnostic markers for the assessment of endothelial dysfunction in type 2 diabetic patients. Tight blood glucose control, regular monitoring of hs-CRP, MDA levels within normal range might be useful for reduction of vascular complications in type 2 diabetic patients

Keywords: Abdominal malignancies, Incidence, Intestinal obstruction, Perforation.