Prevalence of left ventricular diastolic dysfunction in patients with subclinical hypothyroidism

Abstract

Background and Aim:Subclinical hypothyroidism (SCH) is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone (TSH) levels are mildly elevated. Thyroid hormone regulates different cellular and molecular mechanisms by which it exerts action on almost every cell and organ in the body including heart. We tried to ascertain prevalence of LV diastolic dysfunction in patients of subclinical hypothyroidism. Methods: Hospital based study was done in patients of SCH fitting in inclusion and exclusion criteria attending the OPD/IPD of Mahatma Gandhi Hospital, Jaipur.Results:Mean TSH levels in Subclinical Hypothyroidism cases is 7.41±1.57 mU/L, mean Free T4 levels is 1.57±0.38 pmol/L  and Mean Free T3 levels is 4±0.71pmol/L. Mean LVEDD is 47.56±3.24 mm, mean LVESD is 30.518±5.7mm, Diastolic IVST is 9.8±1.49mm, Diastolic LVPWT is 9.8±1.7mm and LVM is 35.81 ±5.7mm.Conclusion: Cardiovascular changes are commonly associated with newly detected Subclinical hypothyroidism. Early diagnosis and correction of hypothyroidism is necessary; so that early effects on cardiovascular system can be minimized.