To evaluate anti-nociceptive activity of Aloe vera gel extract in graded doses in Albino rats by using radiant heat induced pain by using Analgesiometer

Abstract

Background: Pain is a reaction of the body to harmful stimuli and is therefore a protective early warning system, the sensation of pain in postoperative patients, cancer patients, and other chronic pain patients has little positive effect. Objective: To evaluate anti-nociceptive activity of Aloe vera gel extract in graded doses in Albino rats by using radiant heat induced pain by using Analgesiometer. Materials and methods:The present study is undertaken to evaluate the anti-nociceptive effect of Aloe vera in animal models of pain in Albino rats. It was conducted in the Department of Pharmacology, Kamineni Institute of Medical Sciences (KIMS) from October 2012 - September 2014.Results:Aloe vera leaf gel extract powder dissolved in distilled water was evaluated for anti-nociceptive activity in tail flick method in albino rats. Tramadol, the known synthetic opioid analgesic is used as standard drug for comparing the effects of Aloe vera. Aloe vera in the doses of 200mg/kg and 400mg/kg orally produced significant anti-nociceptive effect in tail flick method in comparison to control group (DW). The standard drug tramadol in the dose of 20mg/kg orally also produced significant anti-nociceptive effect in tail flick method in comparison to control group (DW).Conclusion: Aloe vera leaf gel extract powder (dissolved in distilled water) possesses anti-nociceptive activity at 200 mg/kg and 400 mg/kg dosage at 60, 90 and 120 minutes when given orally in tail flick, model in albino rats.