Prevalence of ESBL Producing Gram Negative Bacilli in a Tertiary Care Hospital

Abstract

Introduction: Rapid emergence of ESBL producers in gram negative bacilli has put forward a major challenge worldwide in their detection as well as treatment options for clinicians. Hence for proper management of these resistant bacteria it is so important and essential to correctly identify them. Antimicrobial resistance is now proclaimed as the most important challenge worldwide being faced by humanity in its fight against infectious diseases. Extended Spectrum β-Lactamases (ESBLs) producing bacteria are increasing in number and causing more severe infections because of their continuous mutation and multidrug resistance property which make its difficulty in therapeutic treatment. The aim of this study is to determine the prevalence of extended spectrum beta lactamase (ESBL) producing Gram negative bacteria causing infections among in- and out-patients in a tertiary health care facility. Methodology: This study was conducted at a tertiary care hospital in which gram-negative bacilli which were isolated from patients’ samples. This study was conducted in Department of Microbiology at T.S. Misra Medical college& hospital, Amausi, Lucknow, Uttar Pradesh. The duration of study was over a period of two year from January 2019 to 2021. Results: This result of this study revealed that, 53.9% percent of the bacterial isolates which showed resistant to the third generation cephalosporins were observed to be as ESBL producers. Conclusion: ESBL-producing bacteria are a strain of multidrug-resistant pathogens that are increasing rapidly and becoming a major problem in the region of infectious diseases. It is necessary to report ESBL production along with the routine antibiotic susceptibility reporting, it will help the clinicians in prescribing proper antibiotics for treatment.