A study on epidemiology of HER2/NEU positive breast cancer of patients presented in a tertiary care teaching hospital, Kolkata, West Bengal

Abstract

Background: Breast cancer is the second most common cancer now, after lung cancer, when ranked by cancer occurrence in both sexes. The aim of this study was to determine the correlation between various modifiable and non modifiable risk factors among women with HER2/neu positive breast cancer attending at Medical College and Hospital, Kolkata. Materials & Methods: A cross sectional analytical epidemiological study in Out Patient Department & Emergency Department of General Surgery, Medical College& Hospital, Kolkata. Period of study was between January 2018 to June 2019. All the adult breast cancer patients attending Department of General Surgery, Medical College & Hospital, Kolkata were included in the study and that came out to be 25 HER2 neu positive and 35 HER2 neu negative patients. All together 60 patients were included. Results: We have found 60 patients among them 25 patients were HER2/neu positive and 35 patients were HER2/neu negative i.e. 42% of patients in our study found to be HER2/neu positive. Among these patients the patient with minimum age was 38 years old, and the maximum aged patient was 65 years old.The average age was 57.33 years. The average age of HER2/neu positive group was 57.77 years and the HER2/neu negative group was 56.48 years. About 35% of these patients had history of OCP intake. Among HER2/neu positive patients 57.1% & HER2/neu negative 42.9% had history of OCP intake. Most of the patients in this study are in pre-obese (BMI 25-29.99) class as per BMI. About 18 HER2/neu positive patients and 26 HER2/neu negative patients are within this group. Five (14.28%) patient in HER2/neu negative group and 3 (12%) in HER2/neu positive group has positive family history of breast cancer. In our study we have found that menarche of minimum age of 9 years and maximum age at 15 years. Maximum no. of patients found their menarche at the age of 12 years. Conclusion: From our study and analysis we could not establish any obvious significant difference between epidemiological distributions of breast cancer patients in respect to HER2/neu status. Hence this can be concluded from our study that there is no different epidemiological pattern of breast cancer in respect to HER2/neu status.