A case-control study to determine the relationship between lipid profile and different types of anaemia

Authors

  • Rijhwani P Professor and HOD, Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Sharma V Junior Resident, Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Kalia A Associate Professor, Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Moolrajani K Professor, Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Agrawal C Professor, Department of Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India
  • Gupta S Senior Resident, Department of Neurology, NIMHANS, Bangaluru, India

Keywords:

Anaemia, lipid profile, pallor, fatigue.

Abstract

Aim: To study the relationship between lipid profile and types of Anaemia.Methods: This case (N=154) control (N=154) study was carried out in the Department of General Medicine, Mahatma Gandhi Medical College, Jaipur from January 2019 to June 2020. This includes All proven cases of Anaemia of age >18yrs and Hb<12gm% irrespective of sex. A detailed history was obtained from the subjects of the study, with special emphasis on age, sex and occupation; non-specific symptoms of anaemia. Fasting venous blood sample (> 12 hours) was obtained for estimation of lipid profile. T3 and T4 levels, fasting and post prandial (two hours after an oral dose of 75gms of glucose) blood sugar levels, and bone marrow aspiration cytology was done in selected cases based on clinical assessment. Results: The cases and Controls are matched for Age, majority of the cases (35.1%) and Controls (33%) are in the age group of >50 years. 61.7% of cases are males and 38.3% are females, and 57.8% of Controls are Males and 42.2% are Females. Most common presenting symptom is Fatigue, which was present in 50% of the cases. The most common finding on general physical examination was pallor, which was present in 58.4% cases. Mean Total Cholesterol level is more in IDA (136.6±17.9 mg/dl) compared to other types of Anaemia, mean HDL levels is more in Vit B12 Deficiency Anaemia (31.67±5.4 mg/dl), mean LDL levels is more in Vit B12 deficiency Anaemia (84.7±14.9), mean VLDL levels is more in Dimorphic Anaemia (52.4±25.8 mg/dl), mean TG levels is more in Dimorphic Anaemia. Conclusion: Anaemia is associated with significant hypocholesterolaemia, with lowering in all lipid subfractions. The extent of hypocholesterolaemia is proportional to the severity of anaemia. The type of anaemia has no effect on the hypocholesterolaemia seen in anaemia.

Downloads

Published

2021-08-16

How to Cite

Rijhwani P, Sharma V, Kalia A, Moolrajani K, Agrawal C, & Gupta S. (2021). A case-control study to determine the relationship between lipid profile and different types of anaemia. International Journal of Health and Clinical Research, 4(14), 19–24. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/2218