A comparative evaluation of intubating conditions and haemodynamic changes with Vecuronium and Rocuronium bromide for laryngoscopy- A clinical study

Abstract

Background: The present study was conducted to compare the effect on intubating conditions and haemodynamic changes using Vecuronium and Rocuronium bromide for laryngoscopy. Materials & Methods: The present study was conducted on 40 ASA grade I and grade II patients which were divided into 2 groups of 20 each. Group I patients received Inj. Rocuronium and group II patients received Inj. Vecuronium. Time in seconds from injection of study drug till TOF score 0 (onset time) and duration of action were measured by intermittently noting response to TOF. Parameters such as onset of action, intubating conditions, heart rate and train of four monitoring was recorded. Results: The mean train of four monitoring was 62.4 seconds in group I and 138.2 seconds in group II, duration of action was 42.6 minutes in group I and 46.4 minutes in group II. The difference was significant (P< 0.05). Intra-operative laryngoscopy status was easy in all patients in both groups. The mean heart rate (beats/min) at baseline in group I was 82.4 and in group II was 84.2, after intubation in group I was 91.4 and I group II was 94.6 and after 10 minutes in group I was 80.6 and in group II was 83.1. The difference was significant (P< 0.05). Conclusion: Authors found that both Rocuronium and Vecuronium were found to be equally effective. There was no difference in intubating conditions and haemodynamic response between both agents.