Significance of CRP as a Biomarker in COPD Acute Exacerbation

Authors

  • Sanjay Somashekar Associate Professor, Department of Pulmonary Medicine, SDM College of Medical Sciences & Hospital, Shri Dharmasthala Manjunatheshwara University Dharwad, India
  • Hemareddy Betageri Professor, Department of Pulmonary Medicine, SDM College of Medical Sciences & Hospital, Shri Dharmasthala Manjunatheshwara University Dharwad, India
  • Vinaya KumarJogondra Assistant Professor, Department of Pulmonary Medicine, SDM College of Medical Sciences & Hospital, Shri Dharmasthala Manjunatheshwara University Dharwad, India
  • Shrikant Hiremath Assistant Professor, Department of Pulmonary Medicine, SDM College of Medical Sciences & Hospital, Shri Dharmasthala Manjunatheshwara University Dharwad, India
  • Harsha Hanji Assistant Professor, Department of Pulmonary Medicine, SDM College of Medical Sciences & Hospital, Shri Dharmasthala Manjunatheshwara University Dharwad, India

Keywords:

Chronic obstructive pulmonary disease, C reactive protein, Bacterial exacerbation, Non- Bacterial exacerbation

Abstract

Background:Chronic obstructive pulmonary disease (COPD) exacerbation is a cause of high mortality in COPD patients. C reactive protein (CRP) role in predicting exacerbation has been studied before, but it’s value in Predicting etiology is not well established. In this study the role of CRP to determine the presence of bacterial exacerbations in Indian population was studied which could guide us in early initiation of therapy in these cases.Methods:In this study CRP levels were measured from patient’s serum using nephelometric method. Sputum samples were obtained from COPD Acute exacerbations (AE) patients and evaluated microscopically and subjected to culture. 60 patients with Bacterial exacerbation were compared with 33 patients of Non-Bacterial exacerbation and the relationship between CRP and Bacterial exacerbation was assessed. Results:Using Mann-Whitney U-test, high CRP median values were seen in Bacterial COPD AE as compared to Non-Bacterial COPD AE. The ideal cut-off point in our study for distinguishing Bacterial COPD AE with Non-Bacterial COPD AE was 7.62 mg/l calculated using Youden criteria (sensitivity: 96.67%; specificity:39.39%; PPV:74.36%; NPV:86.67%, AUC:0.64(95% CI: [0.52,0.77])Conclusion:In patients exhibiting symptoms of COPD AE an elevated serum CRP level >7.62mg/l indicates Bacterial exacerbation which might be useful in early initiation of antibiotic therapy in these cases.Abbreviations: COPD: Chronic obstructive pulmonary disease, CRP: C reactive protein, AE: Acute exacerbations

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Published

2021-08-16

How to Cite

Sanjay Somashekar, Hemareddy Betageri, Vinaya KumarJogondra, Shrikant Hiremath, & Harsha Hanji. (2021). Significance of CRP as a Biomarker in COPD Acute Exacerbation. International Journal of Health and Clinical Research, 4(14), 238–241. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/2328