Assesment gene mutations in isoniazid hydrochloride mono resistant mycobacterium tuberculosis

Abstract

Background: The aim of the study is to detect the of genes in isoniazid resistant mycobacterium tuberculosis and to correlate with the genes in multi drug resistant mycobacteria.To describe the INH resistance and level of INH resistance based on LPA in Government General Hospital/ Government Medical College. Meterials and Methods: This study is a retrospective observational study, carried out among INH drug resistant Tuberculosis patients 200 in the department of pulmonary medicine, Government General Hospital/ Government Medical college, Ongole, Andhra Pradesh during the period ie Jan 2018 to Dec2020. A total of 200 patients found to be resistant to INH were enrolled for this study to know the resistant genes. Results: The mean age of study population was 45.56+12.39 .There were 155 (77.5%)males,45(22.5%)were females.Out of 200drug resistant patients 190 (95%)were INH mono resistant,while 10(5%)wereresistant to both INH and Rifampicin drugs.The most common genetic mutations observed in INH monoresistance 115 patients was gene IhA(55.5%) followed by KatG gene observed in 86 patients (43%),where as 3(1.5%) patients have both inhA and KatG genes.