Atypical manifestations of MIS-N associated with asymptomatic maternal prenatal SARS COV-2 infection -A case series
Abstract
As we know COVID-19, caused by SARS-CoV-2, is a global public health crisis. Due to the lack of viral receptors in children's lungs and placenta, children and newborns are fortunately less affected. But sometimes maternal antibodies may cause severe inflammation in neonates in the form of Multisystem inflammatory syndrome (MIS-N). Spike protein antibodies which are usually increased after immunization are protective. These antibodies cross the placenta to provide passive immunity to the newborn. Autoantibodies against endothelial, gastrointestinal, and immune cells are may potentially play a role in MIS-N. Here we are presenting atypical presentations of MIS-N. The role of genetic susceptibility in the pathogenesis of MIS-N needs further investigation.
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Copyright (c) 2021 Tejaswi Reddy, Paramesh Pandala, Mallareddy Ponnathota, Alimelu Madireddy, Rakesh Kotha
This work is licensed under a Creative Commons Attribution 4.0 International License.