Compare the efficacy of oral nifedipine versus intravenous isoxsuprine as tocolytic in arresting preterm labour

Abstract

Introduction: Preterm labour is the leading cause of neonatal mortality and morbidity.it accounts for 75-80% of perinatal mortality and morbidity. The goal of tocolysis is to cause cessation of uterine contractions, arrest the preterm labor for at least 48 hours so that fetal pulmonary maturity is attained with the use of corticosteroids. Aims: To compare the efficacy of Oral Nifedipine versus intravenous isoxsuprine as tocolytic in arresting preterm labour. 2.To compare the side effects of Oral Nifedipine versus Intravenous Isoxsuprine. Materials and methods: A prospective study of Oral nifedipine versus intravenous Isoxsuprine for arresting preterm labour was carried out in the department of Obstetrics and Gynaecology during the period of two years. A total number of 100 cases of preterm labour were taken and grouped equally. Results: 92% cases remained undelivered ( successful tocolysis) at 48 hrs in nifedipine group compared to 76% of cases in Isoxsuprine group. Maternal side effects were noticed in 26% of patients in Nifedipine group, most common side effect being Headache, compared to 50% in Isoxsuprine group most common side effects being Hypotension and tachycardia. Mean birth weight in Nifedipine group was 2.27±0.49 compared to 2.24±0.49 in Isoxsuprine group. Percentage of Neonatal complications in nifedipine group was 32 % compared to 52% in isoxsuprine group, which is statistically significant. Conclusion: In this study it was found that oral Nifedipine has fewer and less serious side effects as compared to I.V Isoxsuprine. Moreover I.V Isoxsuprine requires intensive monitoring of the patients.