Study of liver enzymes and creatine phosphokinase in hyperthyroidism at tertiary care centre

Abstract

Background: Thyroid dysfunction is one of the most common endocrinological disorders. Consequently, abnormalities of these hormones frequently involve many organ systems producing diverse clinical signs and symptoms.Aim and objectives: This study was conducted to evaluate the effects of thyroid hormones on the Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline Phosphatase (ALK) and Creatine Phosphokinase (CPK) levels. Material and Methods: The study was conducted in the Department of Biochemistry laboratory of SRG Hospital, Jhalawar Medical College, Jhalawar (Rajasthan) from May to November 2020. The present study comprised of 50 cases of hyperthyroidism and 50 were euthyroid subjects. The statistical analysis was performed by using SPSS version 17.0 and Microsoft excels 2007. Results: There were significantly increased liver enzymes in hyperthyroidism patients when compared with healthy controls (p value <0.05). The mean serum ALT level were 152.6 ± 61.63 IU/L in cases and 26.078 ± 9.04 IU/L in controls, AST level were 184.658± 83.95 IU/L in cases and 26.39 ± 10.25 IU/L in controls and ALK levels were 305.004 ± 121.35IU/L in cases and 72.87 ± 22.46 IU/L in controls. However serum levels of CPK were significantly (p value <0.05) decreased in cases as compared with controls. The mean serum levels of CPK in cases were 17.624 ± 7.03IU/L and 24.448 ± 8.25IU/L in controls. Conclusion: This study shows the increased serum levels of ALT, AST, and ALK and decreased serum levels of CPK in hyperthyroidism patients, whereas decreased serum levels of ALT, AST, ALK and increased serum levels of CPK in euthyroid subjects.