Prognostic factors for outcome of pregnancy after controlled ovarian hyperstimulation and intra uterine insemination: a prospective study

Abstract

Objective: To identify factors predicting pregnancy after controlled ovarian   hyperstimulation and intrauterine insemination. Design: Prospective observational study. Study was conducted at Fertility unit in department of Obstetrics and gynecology in S.M.S Medical College Jaipur. Methods: 386 stimulated cycles were studied. Couples included in study group had at least one year of infertility and had undergone a basic infertility evaluation consisting of hormonal study, ovulation study, thyroid levels, prolactin levels, ultrasonography, and semen analysis. Ovarian hyperstimulation was done using clomiphene citrate from day 2 to day 5 of cycles and trigger for ovulation was done by injection of beta-HCG. Intrauterine insemination was done after 36 hours of controlled ovarian hyperstimulation. Outcome: Main outcome measured were studied in terms of clinical pregnancy. Results: In all 386 IUI cycles studied, maximum chances of pregnancy were found to be most significantly associated with age and endometrial thickness. Other factors were also studied but no significant association was found. All results were statistically analysed. Conclusion: Intrauterine insemination is an important option for infertile couples. Several factors predict its success rate amongst which endometrial thickness was found to be most significant.