Comparison of the Efficacy of Topical Tacrolimus and Pimecrolimus in Treatment of Stable Vitiligo

Abstract

Background: The topical calcineurin inhibitors (TCIs) are emerging treatment modalities for vitiligo patients. Aim and objective: The aim of this study was to assess the efficacy and tolerability of the TCIs Tacrolimus and Pimecrolimus in vitiligo patients. Methods: A total of 40 patients with vitiligo were enrolled in this study. They were divided into two groups: topical Tacrolimus 0.1% ointment(20) and topical Pimecrolims 1% cream(20). The efficacy of treatment was assessed 2,4,8,12 and 24 weeks. Results: At the end of 24th week, Tacrolimus users showed 25% repigmentation with score of repigmentation 2.62 whereas Pimecrolimus users showed 20% repigmentation with score of repigmentation 2.02. Conclusion: After 24 weeks, Tacrolimus 0.1% users showed more efficacy comparing Pimecrolimus 1% topical drug users.