Efficacy of topical Luliconazole in management of tinea corporis and tinea cruris infections

Abstract

Background: Superficial fungal infections of the skin, hair, and nails are common worldwide with a prevalence of 20–25%, of which dermatophytes are the most common causative agents.As dermatophytic infections of the hair mainly require systemic antifungal therapy, we will focus only on the topical therapy of dermatophytic infections of the skin and nails.Luliconazole is an imidazole antifungal agent that has been shown to have potent activity against a variety of fungi, especially dermatophytes.Aim of the study: Toassess efficacy of topical Luliconazole in management of tineacorporis and tineacruris infections.Materials and methods: The present study was conducted in the Department of Dermatology of the medical institution. The ethical clearance for the study was approved from the ethical committee of the hospital. The present study was conducted on 60 patients with Dermatophytoses involving tineacorporis and tineacruris infections. All patients were informed regarding the study and written consent was obtained. General data such as name, age, gender etc. was recorded. A through clinical examination was done. Patients were instructed to apply luliconazole 1% cream once daily for two weeks. At the end of treatment phase, there was a ‘Follow-up Phase’ at end of two weeks, where the patients were assessed clinically and mycologically for relapse.Results: A total of 60 patients were included in the study. 32 patients were males and 28 were females. The mean age of the patients was 42.69 years. There was a significant reduction in the pruritis with application of Luliconazole topical for the treatment period. The results on comparison were found to be statistically significant. Conclusion:  Within the limitations of the present study, it can be concluded that topical Luliconazole is highly effective for tineacorporis and tineacruris infections.