To Study and Compare the Hemodynamic Effects of Intravenous Magnesium Sulfate and Fentanyl Citrate in Surgical Procedures under General Anaesthesia

Abstract

Objective:  To study and compare the hemodynamic effects of intravenous Magnesium sulfate v/s Fentanyl citrate in surgical procedures, under general anaesthesia.Material and methods: This was a prospective randomized study conducted in our hospital on 60 ASA (American Society of Anaesthesiologists) grade I or II patients, of either sex, aged 18-45 years, scheduled for elective surgeries, fulfilling inclusion and exclusion criteria, requiring general anaesthesia with endotracheal intubation. The patients were randomized in two groups of 30 each- F Group patients were given Fentanyl citrate as the study drug while M Group patients were given Magnesium sulfate as the study drug. Randomization was done as per week days like those posted for surgery on Monday were included in group M; and those on Tuesday were included in group F and so on. Results: It was observed that-Pulse rate reached near baseline value at 5 minutes after intubation in F group, while in 10 min. after intubation in M group.1) 5 min. after study drug, the fall in SBP was significant in M group (1.29%) but insignificant in F group (0.03%).2) After 5 min. of giving study drug, DBP decreased in F group (insignificantly) but decreased significantly in M group (9.99%). 3) 5 min. after study drug, the fall in MAP was more in M group (1.96%) than in F group (0.61%).Conclusion: Magnesium sulfate provides intraoperative hemodynamic stability like Fentanyl citrate; although the hemodynamic stability provided by Magnesium sulfate is not superior to that provided by Fentanyl citrate.