Evaluation of efficacy of dexmedetomidine in providing haemodynamic stability during intraoperative and postoperative period in patients undergoing Total laparoscopic hysterectomy

Abstract

Background: Laparoscopic surgery is a modern surgical technique involving insufflation of gas (usually Co2) into the peritoneal cavity under pressure to separate the organs from the abdominal cavity. This placebo controlled, double blind, prospective study is designed to evaluate the efficacy of dexmedetomidine in providing haemodynamic stability during perioperative period in patients undergoing laparoscopic hysterectomy. Materials and methods: It was a Prospective, randomized, double blind, clinical study was conducted during from January 2017 to Jan 2019, sixty patients scheduled to undergo elective laparoscopic hysterectomy. under general anaesthesia were enrolled in the study. Results: Comparison of mean recovery time in minutes- The mean duration of extubation time in Dexem group was 7.1 ± 0.58/mins and in control group it was 6.74±0.73 /mins. The mean duration of response to oral commands in Dexem group was 8.78±0.72/mins and in control group it was 8.66 ± 0.73 /mins. There was no statistically significant difference found in the extubation time and response to oral commands (P>0.05). Conclusions: We conclude from our study that, Dexmedetomidine iv infusion in the dose range of 0.2μg/kg/hr reduces the rise in heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure associated with the creation and maintenance of pneumoperitoneum during the laparoscopic surgical procedures.