Prospective Study of Expression of P53 in Ovarian Cancer and it's Correlation with Clinicopathological Parameters in a Tertiary Care Hospital

Authors

  • KP Umadevi Associate Professor, Department of Pathology, Aarupadai Veedu Medical College & Hospital, Puducherry,India
  • Jawahar Ramasamy Professor, Department of Pathology, Aarupadai Veedu Medical College & Hospital, Puducherry, India
  • Jeya shambavi.J Associate Professor, Department of Pathology, Aarupadai Veedu Medical College & Hospital, Puducherry,India
  • S Revathy Assistant Professor, Department of Pathology, Aarupadai Veedu Medical College & Hospital, Puducherry, India

Keywords:

Ovarian cancer, p53 expression, CA-125.

Abstract

Introduction: Ovarian cancer is the 6th most common cancer in women worldwide. It is the 5th leading cause of death among women in the developed countries. The incidence rate is higher in white women followed by Hispanic, Asians, Black and American Indian women.Materials and Methods: The present study was a single-centre, prospective study. Total 36 histopathologically diagnosed cases of serous carcinoma were considered in the present study. Based on recent two-tier binary grading system, Serous ovarian carcinoma was histologically classified into low grade and high grade. All the relevant clinical history, investigation findings and serum CA-125 value were collected from patient case file. Staging was performed according to FIGO criteria. Immunohistochemical staining was done for p53 with Dako Flex monoclonal mouse anti-human p53 protein clone DO-7 over FFPE tissue sections which were mounted on poly-L-Lysine coated slides.Results: Out of total 36 cases of serous carcinoma, 28 cases were high grade serous carcinoma and 8 cases were low grade serous carcinoma (Table 1). All the cases were in the age group of 40 to 60 years of age group. In the present study (Table 2), it was observed that, out of 28 HGSOC cases, 22 cases (78.57%) were diagnosed in advanced stages (FIGO Stage III and IV) while 6 out of 8(75%) cases of LGSOC were diagnosed in comparatively earlier stages (FIGO stage I and II).Conclusion: The significant difference of p53 expression between low grade and high grade serous carcinoma of ovary strongly suggests that the underlying pathogenesis of these two tumours is different. Higher p53 expression mainly in high grade carcinoma suggests its prominent role in the pathogenesis of high grade serous carcinoma of ovary. Further association of high grade serous ovarian carcinoma with advanced FIGO stages and higher CA-125 value suggests aggressive nature of this tumour.

Downloads

Published

2021-11-08

How to Cite

KP Umadevi, Jawahar Ramasamy, Jeya shambavi.J, & S Revathy. (2021). Prospective Study of Expression of P53 in Ovarian Cancer and it’s Correlation with Clinicopathological Parameters in a Tertiary Care Hospital. International Journal of Health and Clinical Research, 4(19), 214–216. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/3093