Comparison between Buprenorphine and Clonidine as an adjuvant to intrathecal Bupivacaine for abdominal hysterectomy

Abstract

Background:This study was planned to compare the block characteristics, intraoperative haemodynamic changes, duration of postoperative analgesia and perioperative complications between buprenorphine and clonidine when used as an adjuvants to intrathecal hyperbaric bupivacaine. Methodology:This was randomized comparative study on 108 females who underwent hysterectomy. Hemodynamic parameters, onset and duration of sensory and motor block were noted and also intra as well as post operative complications were noted and the findings were compared between 3 groups. Results: The time of onset of Sensory Block, motor block , duration of sensory and motor block were significantly higher in buprenorphine group as compared to clonidine and bupivacaine alone group. In present study, incidence of bradycardia as well as hypotension was significantly higher in group C as compared to group B and group A (p<0.05). However, intraoperative pain was significantly higher in group A as compared to other 2 groups (p<0.05). Conclusion:Buprenorphine is preferable than clonidine as an adjuvant with hyperbaric bupivacaine in patients posted for abdominal hysterectomy under spinal anaesthesia for better intraoperative haemodynamic stability and prolonged period of postoperative analgesia.