Stromal expression of cd10 in invasive breast carcinoma and its correlation with ER, PR, HER2, NEU and KI67
Keywords:CD10, Her2. Ki67 index, Medullay Carcinoma, stromal positivity, Immunohistochemical
Aim & Objective: To evaluate and correlate CD10 expression with ER, PR, HER2-Neu & Ki 67 index CD 10 expression in breast malignancies. Methodology : The descriptive study was undertaken in the Upgraded Department of Pathology, Osmania medical college, Hyderabad from Dec 2015 to June 2017.Total of 50 cases of invasive breast carcinomas in females were included in the study. Of these 45 cases comprised of invasive carcinoma of no special type (NST) followed by 3 cases of invasive lobular carcinoma and the remaining 2 cases were medullary carcinoma and tubular carcinoma respectively. Results: In the present study, the age group included were from 35-80 years with the average age being 51years and highest incidence of breast carcinoma was seen in fourth decade. Routine processing and Haematoxylin and Eosin staining of the received specimens were done followed by immunohistochemical analysis with CD10, ER, PR, HER2neu & Ki 67 antibody was done. In the present study, cytoplasmic and membranous staining of >30% of the stromal cells around the tumor cells were taken as CD 10 stromal positivity. CD 10 stromal positivity was correlated with expression of ER, PR, HER2 neu and Ki 67 index. Present study showed a slight lower negative correlation of CD10 stromal expression with ER expression which showed a higher correlation in other studies. This discordance can be attributed to the number of cases and duration of study and also to the more ER positive prevalence in the study group. Present study did not show any correlation with CD 10 expression and PR status which was much similar to the observations in other studies. Present study showed good correlation between stromal CD 10 expression and well established negative prognostic marker that is, HER2 neu overexpression and high Ki 67 index. Conclusion: To conclude, stroma plays a important role in progression, hormonal expression and response to chemotherapy in breast cancer
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Copyright (c) 2021 Y. Niharika Reddy, Sandhya Bangaru, Swathi Taduri, K. Devender Reddy
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