Role of PPAR delta in Obesity and Type 2 Diabetes Mellitus due to Obesity

Abstract

Background: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. The 3 PPAR isotypes, PPAR-alpha, PPAR-gamma, and PPAR-delta, play a key role in the regulation of lipid and glucose metabolism. Obesity and the interrelated disorders of the metabolic syndrome have become a major worldwide health problem. Material and Method: This study included 54 subjects with aim to study Role of Ppar delta in obesity and diabetes mellitus type 2 due to obesity. They were classified into: Group I: Included 15 apparently healthy lean individuals (7 males and 8 females) as control group. Their age ranged from 30 to 57 years, Group II: Included 15 obese non diabetic individuals (6 males and 9 females). Their age ranged from 21 to 65 years and Group III: Included 24 patients with type 2 diabetes mellitus with no diabetic complications (10 males and 14 females). Their age ranged from 33 to 60 years. This group divided into: Group IIIa: Diabetic non obese patients (12 patients) and Group IIIb: Diabetic obese patients (12 patients). Result: Comparison among carriers was found to be statistically significant, among all the parameters. Conclusion: Obesity and diabetes mellitus, critical danger factors for the advancement of CAD, are turning into a worldwide pandemic, which is identified with natural, social, and hereditary factors. Although changes in way of life are compelling in forestalling both diabetes and weight in high-hazard grown-ups with impeded glucose resilience, accomplishing alterations in way of life have shown to be difficult. The excitement for the utilization of PPARs is hosed by their possible oncologic impacts.