Correlation between serum lipid profile with severity of meibomian gland dysfunction

Abstract

Meibomian Gland Dysfunction (MGD) is a chronic diffuse abnormality of themeibomian glands, commonly characterized by terminal duct obstruction andcauses qualitative or quantitative changes in glandular secretion. Both forms of MGD are influenced by endogenous factors like age, sex, hormonal disturbances, lipid profile of the patient and exogenous factors like topical medications. Hence, we have conducted this prospective trial to study the correlation between serum lipid profile with severity of meibomian gland dysfunction at Katuri Medical college. Out of 100 patients we recruited, major of them were 40-50 years of age with female predominance (p<0.03). And most of them 40.5% had belonged to grade 2. The severity had positive association with age >50 had grade 3 and 4 more. 70/100 had triglyceride (TG)level >150 mg/dl. 86.66% among them had 4 severity(p 0.03). 60/100 had > 200mg/dl of the cholesterol (CH) level 80% of them had Grade 4 MSD followed by 74.07% of grade 3 (p 0.02). Among the patients with <40 mg/dl of the HDL level, about 93.33% of them had the grade 4 severity. By these finding we would like to conclude that, severity of MGD has strong positive corelation with age, female gender, high TG and CH levels.