Comparative Assessment of Fusidic Acid and Mupirocin in Patients Suffered from Impetigo

Abstract

The data generated from the present study concludes that the Mupirocin Ointment had shown more efficacy as compared to Fusidic acid cream in the selected patients.  The usage of topical treatment for impetigo, mainly with Mupirocin and Fusidic acid is still prevalent today. It has the advantage of minimizing antibiotic resistance, although recent study done in Greece demonstrated increased resistance to these products among certain staphylococcal clone. Topical anti bacterial are used to accelerate clinical cure, prevent recurrences in affected individuals, and to minimize the spread of infection. They are considered more appropriate as they target only infected area and thus avoid the side effects of the oral treatment and the associated drug interactions. Indiscriminate and universal use of topical medications including antibiotics has led to widespread resistance (molecular, group, and class) to the same. Hence based on above conditions present study was planned for Comparative Assessment of Fusidic Acid and Mupirocin in Patients Suffered from Impetigo. Methodology:The present study was planned in Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India,from nov 2019 to April 2020. In the present study 50 patients diagnosed with the impetigo were enrolled. The patients were divided into two groups as 2% fusidic acid cream with topical 2% mupirocin ointment. The diagnosis of impetigo was confirmed clinically. Scoring system of the lesions was done with reference to parameters like erythema, edema, vesiculation, pustulation and crusting.

Keywords: Fusidic Acid, Mupirocin, Impetigo, treatment, etc.