A prospective study on clinical manifestations of paraphenylene diamine containing hair dye poisoning

Authors

  • K N Sree Sai Gayathri Assistant Professor Department Of Medicine, Gandhi Medical College and Hospital, Secunderabad, Telangana, India
  • Sirisha Peddi Assistant Professor Department Of Medicine, Gandhi Medical College and Hospital, Secunderabad, Telangana, India
  • P. Swetha Assistant Professor Department Of Medicine, Gandhi Medical College and Hospital, Secunderabad, Telangana, India
  • Harsha Vardhan Assistant Professor Department Of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India

Keywords:

Paraphenylene diamine, Clinical manifestations, Complications.

Abstract

Introduction: In the developing countries like ours Pesticide poisoning is one of the leading contributors to this preventable tragedy. Recently, Hair dye poisoning is emerging as an important etiological factor. Hair dye consumption is not an uncommon means of intentional self-harm. Hair dye is available in various forms. It’s cheap and easily available form is Hair dye with chief constituent chemical Para-phenylenediamine (PPD). Aims: To study various clinical manifestations of Paraphenylene diamine containing Hair dye poisoning and to observe the temporal sequence of symptoms, Laboratory profile in the patients and relative frequency of complications and their outcome. Materials and methods: It is Prospective Observational Study done in Medical wards and acute medical care unit. Study done on Clinical presentations, Complications, Laboratory profile, Mortality and Treatment of cases of paraphenylene diamine hair dye ingestion were noted. Patients of alleged hair dye ingestion were taken up for study after the exclusion criteria were ruled out. Results: It was observed that the tendency of poisoning by hair dye was more in females than in males and was more in the age group of 15 – 30 years, as with any other poisoning. The symptoms and signs that were observed in this study are burning pain in mouth / throat / abdomen, vomiting, cervicofacial edema, dysphagia etc. The order of chronology of development of these symptoms was burning pain in mouth / throat / abdomen with vomiting within first 40 – 60 minutes maximum upto 120 minutes, followed by development of cervicofacial edema, dyspnea and dysphagia after few hours. A significant statistical correlation was found to exist between development of AKI and the levels of CPK in blood, rhabdomyolysis. Antihistamines, steroids and maintenance of good hydration along with diuresis form the mainstay of therapy. Conclusion: As the burden of handling hair dye cases has been increasing in this part of the state also, primary care physicians, intensive care physicians and nephrologists need to be aware of its clinical manifestations and management. One should be vigilant of the anticipated complications and be prompt in instituting good supportive management to minimize the morbidity and mortality.

Downloads

Published

2021-12-24

How to Cite

K N Sree Sai Gayathri, Sirisha Peddi, P. Swetha, & Harsha Vardhan. (2021). A prospective study on clinical manifestations of paraphenylene diamine containing hair dye poisoning. International Journal of Health and Clinical Research, 4(23), 63–70. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/3629