A cross-sectional study to explore the correlation of serum Vitamin D3 with laboratory parameters among COVID-19 patients of a tertiary care centre of Uttar Pradesh, India
Keywords:CT value, Pearson’s correlation test, Immunomodulator, D-dimer
Background: There have been a few published studies regarding the significance of Vitamin D levels as a predictor of disease severity, amongst other biomarkers like D-Dimer, CRP, and Ferritin in previous disease outbreaks like H1N1 and SARS. Therefore, the present study aimed to explore the association of Vitamin D3 levels with other laboratory parameters including D3 with biochemical, inflammatory markers and CT Value of COVID-19 patients admitted to Government Institute of Medical Sciences, Greater Noida, a tertiary care hospital during pandemic. Methods: This was a cross sectional study that enrolled 67 RTPCR positive patients over a period of 3 months (May 2020 to August 2020) after obtaining institutional ethical approval. Blood tests for collected blood samples were performed in an appropriate autoanalyzer after complying internal quality control. The correlation between Vitamin D levels and other lab parameters was assessed using Pearson correlation test. The comparison of quantitative variables (biochemical, inflammatory markers and CT Value) between groups was performed using the student’s t test. All statistical analyses were carried out at 5% level of significance and p-value 0.05 was considered significant. Results : The present study enrolled 67 COVID-19 patients out of which only 61 patients had validated measurement of serum Vit D levels. The mean age of the patients was 36.36±10.43 years. The mean serum Vit D level (ng/mL) was 20.99±14.97 and 62.3% of patients (38/61) were having Vit D deficiency. The serum ALP levels (U/L) were significantly higher among Vit D deficient patients on student’s t test analysis (Group 1: 244.64±106.93 vs Group 2: 187.46±70.00; t test value: -2.522, df: 58.565 and p value: 0.014). Conclusions: Although an inverse correlation was seen between serum Vit D and uric acid, the effect of Vit D deficiency in COVID-19 progression or disease severity is far yet to be assessed. The role of Vit D in the management of COVID-19 needs strong randomized control trial (RCT) evidence, but until then physicians should continue to treat deficiency and insufficiency of Vitamin D among COVID-19 patients, as there are hardly any adverse effects.
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Copyright (c) 2021 Mamta Padhy, Hariom Kumar Solanki, Ravoori Saideswar Rao, Ajay Kumar Garg, Manisha Singh, Vivek Gupta
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