A Hospital Based Prospective Study to Compare the Efficacy of Drotaverine Hydrochloride and Valethamate Bromide on Cervical Dilation in Active Labour at Tertiary Care Center
Keywords:Primigravida, Multigravida, Labor, Drotaverine, Valethamate.
Background: Labor is the most perilous journey a woman has to undertake. The present study was done to compare the efficacy of Drotaverine hydrochloride and Valethamate bromide on cervical dilatation in active labour in relation to a control group. Materials & Methods: This was a prospective study conducted in a tertiary center over a span of 12 months period. 150 patients were randomly allotted in 3 groups. 50 patients- control group, 50 patients– Injection Drotaverine and 50 patients – Injection Valethamate bromide. All these patients were entered into partograms and the progress of labour, uterine contractions and the fetal heart rate were monitored carefully. Appropriate non-parametric tests, X2 test and analysis of variants (ANOVA) were applied for assessment of statistical significance. Results: Our study showed that maximum no. of patients (73%) in 21-30 years of age groups. In all the three groups both primigravida and multigravida were included, but not statistical significant (P>0.05). The present study showed that both the drugs shorten the duration of first stage of labor when compared to control, but Drotaverine reduces the duration more than Valethamate bromide. Both in primi and multi this difference was statistically significant. Conclusion: We conclude that effect of Drotaverine on shortening duration of labour is significantly better than Valethamate with fewer side effects. Thus, Drotaverine is a safe, potent and effective drug to shorten the first stage of labour.
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Copyright (c) 2021 Sushma Shikha, Kumar Devashish, Prerna Tejaswi, Seema
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