Comparison of endocrine and metabolic characteristics of lean and overweight/ obese women with PCOS

Abstract

Abstract
Aims & objective :1. To study clinical features in lean and overweight/obese women with PCOS 2. To compare the hormonal assays between lean and overweight/obese women PCOS 3. To evaluate the metabolic parameters in lean and overweight/obese women with PCOS .Material & Methods :This was a prospective observational study conducted in Jehangir Hospital, Pune.from 1st December 2014 to 31st August 2015. All women with a history of oligo/ amenorrhea and clinical signs of hyperandrogenism like acne or hirsutism, were enrolled in the study. Patients fulfilling at least two out of three Rotterdam Consensus revised diagnostic criteria of PCOS were recruited. A detailed history was taken and examination done. Women were stratified into 2 groups lean and overweight/obese on the basis of BMI. All women were subjected to blood hormonal and metablic profile and USG pelvis. Differences in endocrine and metabolic parameters were studied Results :There was more marked hyperinsulinemia [4%vs 3.3%], relative hyperglycemia[8.1% vs 2.1%], with deranged lipid profile [25.1%vs 10.3%]in the overweight/obese women as compared to lean women with PCOS.The LH level was higher in the non obese[33.3%] PCOS group as compared to the overweight/obese PCOS [22.5%] .Conclusion :Extensive efforts should be made to fully investigate the syndrome in order to make lifestyle changes to delay the serious longterm effects of the disease
Keywords: PCOS, Diabetes Mellitus, BMI, Glucose, Lipid Profile, Insulin, Insulin Resistance, Hirsutism.