Correlation of Hematological Parameters in Covid Positive Patients with The Severity of their Illness at A Teaching Hospital in India

Abstract

Introduction: This study was done to evaluate importance of hematological parameters to identify severity of covid 19 positive patients. So that, it will be evaluated who need ICU or emergency treatment. A comparison of biomarkers from the peripheral blood between the covid 19 and non-covid 19 has been done. A comparable study with respect to age, gender and clinical complaints between covid 19 and non-covid 19 patients has been performed. Materials and Methods: A retrospective study was conducted at Autonomous government medical college society of Firozabad on 150 covid positive confirmed patients who were admitted in the covid hospital. Data was collected from the record section of this institute.
Result: As covid 19 is a systemic infection involving multiple systems of the body but the hematopoietic system and hemostasis showed the major impact. Leukocytosis with neutrophila, lymphocytopenia, thrombocytopenia along with raised PT, APTT and D-dimer were reported with poor prognostic potential. Biomarkers such as serum ferritin, serum pro-calcitonin, CRP, interleukin 6 proved to be the important inflammatory marker, which are associated with the severity of the covid 19 positive patients so that proper intervention should be taken at the appropriate time.
Conclusion: Laboratory tests were found to be useful in the diagnosis and management of the disease. Hematological abnormalities included lymphopenia, neutrophilia, thrombocytopenia, and slight fall of hemoglobin. CD4+ and CD8+ T lymphocytes count declined as the disease aggravated.