Comparative study of Bupivacaine and Ropivacaine in combination with fentanyl for Epidural anaesthesia in labour- A Randomized Controlled Trial

Authors

  • Pradeep Kumar Das Associate Professor, Department of Anaesthesia, Great Eastern Medical school & Hospital, Ragolu, Srikakulam, Andhra Pradesh, India
  • Jayachandra Tentu Assistant Professor, Department of Anaesthesia, Great Eastern Medical School & Hospital, Ragolu, Srikakulam, Andhra Pradesh, India
  • Bhyravajosula Koumudi Assistant Professor, Department of Anaesthesia, Great Eastern Medical School & Hospital, Ragolu, Srikakulam, Andhra Pradesh, India
  • Danda Vijaya Kumar Assistant Professor, Department of Anaesthesia, Government Medical College, Srikakulam, Andhra Pradesh, India

Keywords:

ropivacaine, Bupivacaine, epidural, fentanyl, labor, analgesia, obstetrics outcome.

Abstract

Introduction: Effective pain relief during labor is essential to reduce maternal and perinatal morbidity arising due to pain-induced maternal sympathetic activation, and to avoid unnecessary caesarean sections performed due to maternal anxiety. Despite the extensive use and relative safety of bupivacaine, newer drugs such as ropivacaine have been developed as alternative agents to decrease the risk for cardiac and central nervous system toxicity. Objective: To compare the effects on obstetric and neonatal outcomes between ropivacaine and bupivacaine in combination with fentanyl used in walking epidural analgesia.Materials and Methods: One hundred women who demanded epidural analgesia in active labor were randomly allocated into two groups; one group received 20 mL of ropivacaine 0.125% with fentanyl 50 μg and the other received 20 mL of bupivacaine 0.125% with fentanyl 50 μg. The efficacy of analgesia, adverse effects, and obstetric and neonatal outcomes of both groups were compared. SPSS was used for analysis. Results: There were no differences between the two study groups in the measured obstetric and neonatal outcomes. The onset time, duration of analgesia, and sensory levels were similar between the groups. Visual analog pain scale scores did not differ between the groups before analgesia or at any of the subsequent evaluation periods. Conclusion: Both ropivacaine and bupivacaine provide equivalent labor analgesia with high maternal satisfaction and tolerable adverse effects in the clinically used dose range.

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Published

2022-01-18

How to Cite

Pradeep Kumar Das, Jayachandra Tentu, Bhyravajosula Koumudi, & Danda Vijaya Kumar. (2022). Comparative study of Bupivacaine and Ropivacaine in combination with fentanyl for Epidural anaesthesia in labour- A Randomized Controlled Trial. International Journal of Health and Clinical Research, 5(1), 179–182. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/3972